3-Acetyldeoxynivalenol is a trichothecene mycotoxin produced by Fusarium species, exhibiting dose-dependent reduction of lymphocyte proliferation in mitogen-induced blastogenesis, albeit less potently than deoxynivalenol. In a comparative study of deoxynivalenol and its 3- and 15-acetyl derivatives on transepithelial transport, gene expression, and cytokine secretion in human intestinal cell Caco-2, all metabolites could induce mRNA expression and production of IL-8, with 3-acetyldeoxynivalenol being less potent than it 15-acetyl analogue. 3-Acetyldeoxynivalenol induces lysosomal membrane permeabilization-mediated apoptosis and inhibits autophagic flux in macrophages.
| Molecular Formula | C17H22O7 |
| References |
Atkinson HA and Miller K (1984) Inhibitory effect of deoxynivalenol, 3-acetyldeoxynivalenol and zearalenone on induction of rat and human lymphocyte proliferation. Toxicol. Lett. 23:215 Kadota T et al (1888) Comparative study of deoxynivalenol, 3-acetyldeoxynivalenol, and 15-acetyldeoxynivalenol on intestinal transport and IL-8 secretion in the human cell line Caco-2. Toxicol. In Vitro 27:1888 Liu N et al. 3-Acetyldeoxynivalenol induces lysosomal membrane permeabilization-mediated apoptosis and inhibits autophagic flux in macrophages. Environ. Pollut. 265 (Pt B):114697 |
