3-Hydroxy-L-tyrosine methyl ester (melevodopa, L-dopa methyl ester) is a prodrug of levodopa used for the treatment of Parkinson’s disease. L-DOPA methyl ester is a potent competitive antagonist for the action of L-DOPA. Short-term exposure to L-DOPA methyl ester inhibits the induction of endogenous xenotropic type-C virus from Kirsten sarcoma-virus-transformed BALB/c (K-BALB) mouse cells. L-DOPA methyl ester has weak activity against against L1210 and P388 murine leukaemias and B-16 melanoma cell lines.
| Molecular Formula | C10H13NO4 |
| References |
Hickey P and Stacy M (2011) Available and emerging treatments for Parkinson’s disease: A review. Drug Design Dev. 5:241 Goshima Y et al (1980) L-dopa methyl ester antagonizes competitively L-dopa-induced facilitation of noradrenaline release from rat hypothalamic slices. Japan J Pharmacol. 52:174 Suk et al (1981) Inhibition of endogenous murine retrovirus expression by L-β-3,4-dihydroxyphenylalanine (L-dopa) methyl ester. Int. J. Cancer 27:37 |
