SKU: H056  / 
    CAS Number: 1421-65-4

    3-Hydroxy-L-tyrosine methyl ester

    RM327.75 - RM1,140.00

    3-Hydroxy-L-tyrosine methyl ester (melevodopa, L-dopa methyl ester) is a prodrug of levodopa used for the treatment of Parkinson’s disease. L-​DOPA methyl ester is a potent competitive antagonist for the action of L-​DOPA. Short-term exposure to L-​DOPA methyl ester inhibits the induction of endogenous xenotropic type-​C virus from Kirsten sarcoma-​virus-​transformed BALB​/c (K-​BALB) mouse cells. L-​DOPA methyl ester has weak activity against against L1210 and P388 murine leukaemias and B-16 melanoma cell lines.

    Molecular Formula  C10H13NO4

    Hickey P and Stacy M (2011)  Available and emerging treatments for Parkinson’s disease: A review. Drug Design Dev. 5:241

    Goshima Y et al (1980)  L-​dopa methyl ester antagonizes competitively L-​dopa-​induced facilitation of noradrenaline release from rat hypothalamic slices. Japan J Pharmacol. 52:174

    Suk et al (1981)  Inhibition of endogenous murine retrovirus expression by L-​β-​3,​4-​dihydroxyphenylalanine (L-​dopa) methyl ester. Int. J. Cancer 27:37