4-epianhydrotetracycline HCl (tetracycline impurity D) is a degredation compound of the polyketide antibiotic, tetracycline. 4-epianhydrotetracycline is thought to form in samples of improperly stored tetracycline especially in warm, moist, and acidic environments. Studies using rats have shown 4-epianhydrotetracycline to cause renal toxicity and a decrease in mitochondrial respiration.
|Molecular Formula||C22H22N2O7 · xHCl (lot specific)|
Benitz, K. F., and H. F. Diermeier. "Renal Toxicity of Tetracycline Degradation Products." Experimental Biology and Medicine 115.4 (1964): 930-35. Rsmjournals.com. Web. 7 May 2013.Fike, Winston W., and Nicholas W. Brake. "Modified Method for Determining Tetracycline, 4-epitetracycline, and Anhydrotetracyclines in Tetracycline Base or Hydrochloride." Journal of Pharmaceutical Sciences 61.4 (1972): 615-17. Onlinelibrary.com. Web. 7 May 2013.