7-Oxostaurosporine is the oxidised and highly fluorescent analogue of UCN-01 and UCN-02. 7-Oxostaurosporine is a potent inhibitor of protein kinase C and formation of cellular blebs induced by phorbols. 7-Oxostaurosporine possesses comparable activity against tumor cells lines to UCN-01. Despite its close relationship to UCN-01 and staurosporine, limited access to the metabolite has restricted a more complete investigation of its properties.
7-Oxostaurosporine is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
7-Oxostaurosporine is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
| Mechanism of Action | 7-Oxostaurosporine inhibits the cell cycle at the G2 stage with the accumulation of 4C DNA cells |
| Molecular Formula | C28H24N4O4 |
| Documents | A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). I Taxonomy and biological activity. Osada, H. et al. , J. Antibiot. 1992, 45, 189. A new inhibitor of protein kinase C, RK-1409 (7-oxostaurosporine). II Fermentation, Isolation, Physico-chemical properties and structure. Koshino H. et al. , J. Antibiot. 1992, 45, 195. |
