A 26771B is a 16-membered macrocyclic lactone isolated from Penicillium turbatum patented and then published by Eli Lilly and Co. in 1975. A 26771B is closely related to the berkeleylactones, recently reported as antibiotics derived from a cofermentation of P. fuscum and P. camenbertii/clavigerum. A 26771B shows potent activity in vitro against Gram-positive bacteria and moderate activity against a broad selection of fungi. A 26771B inhibits potassium dependent ATPase in rat liver mitochondria.
| Molecular Formula | C20H30O7 |
| References | Canova S et al (2011) Synthesis and biological properties of macrolactam analogs of the natural product macrolide (-)-A 26771B. Bioorg. Med. Chem. Lett. 21:4768 Michel KH (1977) The isolation and structure elucidation of macrocyclic lactone antibiotic.J. Antibiot. 30: 571 Stierle AA et al (2017) The berkeleylactones, antibiotic macrolides from fungal coculture. J. Nat. Products 80:1150 Tatsuta K et al (1980) Stereospecific total synthesis and absolute configuration of a macrocyclic lactone antibiotic, A26771B. Tetrahedron Letters 21:1479 |