SKU: A187  / 
    CAS Number: 56448-20-5

    A 26771B

    $119,812.29 - $417,560.91
    A 26771B
    • Detailed Description

      CAS Number: 56448-20-5

      Molecular Formula: C20H30O7  

      Molecular Weight: 382.5

      Tariff Code: 3822.00.5090

    • Specifications

      Form: Solid

      Appearance: White solid

      Source: Penicillium sp.

    • Technical Data

      Solubility: Soluble in ethanol, methanol, DMF or DMSO.

    • References

      References:

      Canova S et al (2011)  Synthesis and biological properties of macrolactam analogs of the natural product macrolide (-)-A 26771B. Bioorg. Med. Chem. Lett. 21:4768

      Michel KH (1977)  The isolation and structure elucidation of macrocyclic lactone antibiotic.J. Antibiot. 30: 571

      Stierle AA et al (2017)   The berkeleylactones, antibiotic macrolides from fungal coculture. J. Nat. Products 80:1150

      Tatsuta K et al (1980) Stereospecific total synthesis and absolute configuration of a macrocyclic lactone antibiotic, A26771B. Tetrahedron Letters 21:1479

    A 26771B is a 16-membered macrocyclic lactone isolated from Penicillium turbatum patented and then published by Eli Lilly and Co. in 1975. A 26771B is closely related to the berkeleylactones, recently reported as antibiotics derived from a cofermentation of P. fuscum and P. camenbertii/clavigerum. A 26771B shows potent activity in vitro against Gram-positive bacteria and moderate activity against a broad selection of fungi. A 26771B inhibits potassium dependent ATPase in rat liver mitochondria.

     

    CAS Number: 56448-20-5

    Molecular Formula: C20H30O7  

    Molecular Weight: 382.5

    Tariff Code: 3822.00.5090

    Form: Solid

    Appearance: White solid

    Source: Penicillium sp.

    Solubility: Soluble in ethanol, methanol, DMF or DMSO.

    References:

    Canova S et al (2011)  Synthesis and biological properties of macrolactam analogs of the natural product macrolide (-)-A 26771B. Bioorg. Med. Chem. Lett. 21:4768

    Michel KH (1977)  The isolation and structure elucidation of macrocyclic lactone antibiotic.J. Antibiot. 30: 571

    Stierle AA et al (2017)   The berkeleylactones, antibiotic macrolides from fungal coculture. J. Nat. Products 80:1150

    Tatsuta K et al (1980) Stereospecific total synthesis and absolute configuration of a macrocyclic lactone antibiotic, A26771B. Tetrahedron Letters 21:1479