SKU: A200  / 
    CAS Number: 42228-92-2

    Acivicin

    $29,768.90 - $104,240.60

    Acivicin is a chlorinated amino acid originally isolated from Streptomyces sviceus that inhibits glutmate metabolism. It has antifungal, antitumor and antileishmanial properties. Acivicin competitively inhibits amidophosphoribosyl-transferase, CTP synthetase and carbamoyl-phosphate synthetase II from extracts of liver and hepatoma 3924A, and inhibits ALDH4A1.

    Molecular Formula  C5H7ClN2O3
    References

    Mukherjee T et al (1990)  Acivicin: a highly active potential chemotherapeutic agent against visceral leishmaniasis. Mukherjee T. et al. Biochem Biophys Res Commun. 170:426

    Kruezer J et al (2015)  Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition. Chem. Sci. 6:237

    Weber G et al (1982)  Multi-enzyme-targeted chemotherapy by acivicin and actinomycin. Adv Enzyme Regul. 20:75