Acivicin is a chlorinated amino acid originally isolated from Streptomyces sviceus that inhibits glutmate metabolism. It has antifungal, antitumor and antileishmanial properties. Acivicin competitively inhibits amidophosphoribosyl-transferase, CTP synthetase and carbamoyl-phosphate synthetase II from extracts of liver and hepatoma 3924A, and inhibits ALDH4A1.
| Molecular Formula | C5H7ClN2O3 |
| References |
Mukherjee T et al (1990) Acivicin: a highly active potential chemotherapeutic agent against visceral leishmaniasis. Mukherjee T. et al. Biochem Biophys Res Commun. 170:426 Kruezer J et al (2015) Target discovery of acivicin in cancer cells elucidates its mechanism of growth inhibition. Chem. Sci. 6:237 Weber G et al (1982) Multi-enzyme-targeted chemotherapy by acivicin and actinomycin. Adv Enzyme Regul. 20:75 |