Acriflavine Hydrochloride (syn: Acriflavine HCl) is the hydrochloride salt of Acriflavine, a mixture of 3,6-diamino-10-methylacridium (acriflavin) and 3,6-diaminoacridine (proflavin). It was developed in 1912 by Paul Ehrlich, a medical researcher from Germany. It is a fluorescent dye commonly used as a topical contrast agent. It stains cell nuclei and is applied to tissues before miscrocopy. Acroflavine has been used in confocal laser endomicroscopy. The compound has also been used for strain selection.
Acriflavine HCl has both antimicrobial and antiviral properties, and is a potent papain-like protease (PLpro) inhibitor, which inhibits SARS-CoV-2A and other betacoronaviruses. Acriflavine Hydrochloride is freely soluble in aqueous solution.
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