SKU: A204  / 
    CAS Number: 23452-05-3

    Alternariol monomethylether

    $30,757.90 - $107,405.40
    Alternariol monomethylether
    • Detailed Description

      CAS Number: 23452-05-3

      Molecular Formula: C14H10O5

      Molecular Weight: 258.23

      Tariff Code: 3822.00.5090

    • Specifications

      Form: Solid

      Appearance: White to off-white solid

      Source: sp.

    • Technical Data

      Solubility: Soluble in methanol or DMSO

    • References

      References:

      Raistrick H et al (1953)  Studies in the biochemistry of microorganisms. 90. Alternariol and alternariol monomethyl ether, metabolic products of Alternaria tenuis. Biochem. J. 55:421

      Schreck I et al (2012)  The Alternaria mycotoxins alternariol and alternariol methyl ether induce cytochrome P450 1A1 and apoptosis in murine hepatoma cells dependent on the aryl hydrocarbon receptor. Arch. Toxicol. 86:625

      Thomas R (1961)  Studies in the biosynthesis of fungal metabolites. 4. Alternariol monomethyl ether and its relation to other phenolic metabolites of Alternaria tenuis. Biochem. J. 80:234

    Alternariol monomethylether was first reported by Raistrick and colleagues in 1953. Alternariol and its monomethyl ether analogue occur in mycelium of Alternaria tenuis responsible for alternaria cone disorder in hops and fruit spot on papaya (Carica papaya) and Passiflora spp. Alternariol monomethyl ether has broad biological activities, including inhibition of the AhR/ARNT pathway, which mediates induction of CYP1A1 and apoptosis, inhibition of monoamine oxidases and of progesterone synthesis.

     

    CAS Number: 23452-05-3

    Molecular Formula: C14H10O5

    Molecular Weight: 258.23

    Tariff Code: 3822.00.5090

    Form: Solid

    Appearance: White to off-white solid

    Source: sp.

    Solubility: Soluble in methanol or DMSO

    References:

    Raistrick H et al (1953)  Studies in the biochemistry of microorganisms. 90. Alternariol and alternariol monomethyl ether, metabolic products of Alternaria tenuis. Biochem. J. 55:421

    Schreck I et al (2012)  The Alternaria mycotoxins alternariol and alternariol methyl ether induce cytochrome P450 1A1 and apoptosis in murine hepatoma cells dependent on the aryl hydrocarbon receptor. Arch. Toxicol. 86:625

    Thomas R (1961)  Studies in the biosynthesis of fungal metabolites. 4. Alternariol monomethyl ether and its relation to other phenolic metabolites of Alternaria tenuis. Biochem. J. 80:234