- Detailed Description
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Applications
Spectrum: Amoxicillin targets a wide range of β-lactamase negative Gram positive and Gram negative bacteria including E. coli and a number of Streptococcus and Staphylococcus species. Interestingly, Amoxicillin has been found to be effective against certain β-lactam sensitive VRE or vancomycin resistant Enterococcus; a glycopeptide antibiotic resistant "superbug."
Microbiology Applications: Amoxicillin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
- Neisseria gonorrhoeae 0.3 µg/mL - 32 µg/mL
- Haemophilus influenzae 0.125 µg/mL - >64 µg/mL
- For a representative list of Amoxicillin MIC values, click here.
Eukaryotic Cell Culture Applications: Dendritic cells were incubated with supernatant from Amoxicillin-treated hepatocytes to characterize drug-specific signaling pathways between hepatocytes and immune cells to study the influence of the compound on the immune response (Ogese, 2017).
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Specifications
Form: Powder
Appearance: White or almost white crystalline powder
Source: Semi-synthetic
Water Content (Karl Fischer): 11.5%-14.5%
pH: 3.5 - 6.0
Assay: (On Dried Basis): 900-1050 µg/mg
Identification: Conforms (IR)
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Technical Data
Solubility: Benzene: Insoluble
Carbon tetrachloride: Insoluble
Chloroform: Insoluble
Methanol: Slightly soluble
Water: Slightly solubleImpurity Profile: N,N-Dimethylaniline: Meets Requirements
Amoxicillin Trihydrate, USP is an extended spectrum β-lactam antibiotic similar in structure to Ampicillin. Resistance to Amoxicillin can be attributed to β-lactamase enzymes secreted by resistant cells. The compound is effective against a variety of Gram-negative and Gram-positive bacteria.
Amoxicillin Trihydrate is slightly soluble in water.
Ampicillin Trihydrate, USP conforms to United States Pharmacopoeia specifications.
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Spectrum: Amoxicillin targets a wide range of β-lactamase negative Gram positive and Gram negative bacteria including E. coli and a number of Streptococcus and Staphylococcus species. Interestingly, Amoxicillin has been found to be effective against certain β-lactam sensitive VRE or vancomycin resistant Enterococcus; a glycopeptide antibiotic resistant "superbug."
Microbiology Applications: Amoxicillin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
- Neisseria gonorrhoeae 0.3 µg/mL - 32 µg/mL
- Haemophilus influenzae 0.125 µg/mL - >64 µg/mL
- For a representative list of Amoxicillin MIC values, click here.
Eukaryotic Cell Culture Applications: Dendritic cells were incubated with supernatant from Amoxicillin-treated hepatocytes to characterize drug-specific signaling pathways between hepatocytes and immune cells to study the influence of the compound on the immune response (Ogese, 2017).
Form: Powder
Appearance: White or almost white crystalline powder
Source: Semi-synthetic
Water Content (Karl Fischer): 11.5%-14.5%
pH: 3.5 - 6.0
Assay: (On Dried Basis): 900-1050 µg/mg
Identification: Conforms (IR)
Solubility: Benzene: Insoluble
Carbon tetrachloride: Insoluble
Chloroform: Insoluble
Methanol: Slightly soluble
Water: Slightly soluble
Impurity Profile: N,N-Dimethylaniline: Meets Requirements
