Avibactam Sodium is a β-lactamase inhibitor without a β-lactam core that can inhibit class A and C enzymes, along with some class D enzymes. It is effective against Enterobacteriaceae. Avibactam Sodium can be used for strain manipulation and resistance studies. Avibactam Sodium is soluble in water.
| Mechanism of Action | Avibactam is a nucleophilic serine enzyme inhibitor that contains a diazabicyclooctane (DBO) core, unlike the other β -lactamases, or PBPs (penicillin-binding protein) inhibitors, that contain a β -lactam ring. |
| Eukaryotic Cell Culture Applications | Avibactam can restore the antimicrobial properties of partner cephalosporins in vitro against Enterobacteriaceae (Lagacé-Wiens et al, 2011). |
| Molecular Formula | C7H11N3NaO6S |
| References | Abboud I et al (2016) Interaction of Avibactam with class B metallo-B-lactamases. Antimicrob. Agents Chemother. 60(10):5655-5662 PMID 27401561 Ehmann DE (2012) Avibactam is a covalent, reversible, non-B-lactam B-lactamase inhibitor. PNAS 109(29):11663-11668 PMID 22753474 Lagacé-Wiens PS et al (2011) Activity of NXL104 in combination with β-lactams against genetically characterized Escherichia coliand Klebsiella pneumoniae isolates producing Class A extended-spectrum β-lactamases and class C beta-lactamases. Antimicrob. Agents Chemother. 55 (5):2434-2437 PMID 21357295 Lahiri SD et al (2015) Selection and molecular characterization of ceftazidime/avibactam-resistant mutants in Pseudomonas aeruginosa strains containing derepressed AmpC. J. Antimicrob. Chemother 70(6):1650-1658 PMD 25645206 Lahiri, S., Olivier, N., Alm, R., Johnstone, M., & McLaughlin, R. (2014). Avibactam and class C beta-lactamases: Mechanism of inhibition, conservation of binding pocket and implications for resistance. Antimicrob. Agents Chermother. 58(10):5704-5713 |
