Azidamfenicol is a semi-synthetic chloramphenicol in which the nitro moiety is replaced with a methylsulphone and the dichloroacetamide is replaced with azidoacetamide, first synthesised at Bayer in 1959. Azidamfenicol is a broad spectrum antibiotic with good activity against Gram negative and anaerobic bacteria. Azidamfenicol has received little research attention with only a few literature citations.
Azidamfenicol is soluble in ethanol, methanol, DMF and DMSO.
Azidamfenicol is soluble in ethanol, methanol, DMF and DMSO.
| Mechanism of Action | Azidamfenicol acts by binding to the 23S sub-unit of the 50S ribosome, inhibiting protein synthesis. |
| Molecular Formula | C11H13N5O5 |
| References | 1-p-Nitrophenyl-2-azidoacetylaminopropane derivatives. Meiser W. & Domagk G. 1959 US Patent 2,882,275. |