Bacitracin is a branched cyclic dodecylpeptide antibiotic produced by Bacillus licheniformis and some strains of Bacillus subtilis (Azevedo et al 1993). It is synthesized as a mixture of up to 50 closely related congeners/fractions. Bacitracin includes the following fractions: A, B1, B, B2, B3, C, C1, C2, C3, D, E, F, G, H1, H2, H3, I1, I2, I3, and X.
Bacitracin is freely soluble in aqueous solution.
Bacitracin is a polypeptide antibiotic, a mixture composed of related cyclic peptides made by Bacillus licheniformis first isolated in 1945 from the 'Tracy I' variety (ATCC 10716). It was isolated by Balbina Johnson, a bacteriologist at Columbia University. Bacitracin can be synthesized via nonribosomal peptide synthetases (NRPSs). The three-enzyme operon is called BacABC.
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