Beauveriolides are 13-membered cyclodepsipeptides isolated from Beauveria sp.. Beauveriolides I and III inhibit macrophage acyl-CoA:cholesterol acyltransferase (ACAT) activity to block the synthesis of cholesteryl ester, leading to a reduction of lipid droplets in macrophages, inhibiting ACAT1 and ACAT2 to a similar extent. Beauveriolides were orally active in both low-density lipoprotein receptor and apolipoprotein E knockout mice. Beauveriolide I was identified as a potent anti-aging compound from a rapid screening method using budding yeast.
