Beauveriolides are 13-membered cyclodepsipeptides isolated from Beauveria sp.. Beauveriolides I and III inhibit macrophage acyl-CoA:cholesterol acyltransferase (ACAT) activity to block the synthesis of cholesteryl ester, leading to a reduction of lipid droplets in macrophages, inhibiting ACAT1 and ACAT2 to a similar extent. Beauveriolides were orally active in both low-density lipoprotein receptor and apolipoprotein E knockout mice. Beauveriolide I was identified as a potent anti-aging compound from a rapid screening method using budding yeast.
| Molecular Formula | C27H41N3O5 |
| References |
Mochizuki et al (1993) The structures of bioactive cyclodepsipeptides, beaveriolides I and II, metabolites of entomopahtogenic fungi Beavueria sp. Bul.l Chem. Soc. Jpn. 66: 3041 Nakaya S et al (2012) New rapid screening method for anti-aging compounds using budding yeast and identification of beauveriolide I as a potent active compound. Biosci Biotechnol. Biochem. 76:1226 Namantane I et al (1999) Beauveriolides, specific inhibitors of lipid droplet formation in mouse macrophages, produced by Beauveria sp. FO-6979. J. Antibiot. 52:1 Tomoda H and Doi T (2008) Discovery and combinatorial synthesis of fungal metabolites beauveriolides, novel antiatherosclerotic agents. Acc. Chem. Res. 41:32 |
