Camptothecin (Mappia foetida) is an alkaloid topoisomerase l (topo l) inhibitor isolated from the fungus Mappia foetida. The compound has anti-cancer properties.
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| Mechanism of Action | Camptothecin inhibits DNA religation in the cleavage/religation step by binding to DNA topoisomerase I (topo I) and DNA which forms a DNA topoisomerase I - camptothecin - DNA complex. This complex causes DNA damage and leads to apoptosis. |
| Impurity Profile | A:RRT0.90 Impurity: Not more than 0.3% B:RRT1.45 Impurity: Not more than 0.5% Total Impurities: Not more than 1.0% |
| Cancer Applications | Camptothecin has poor water solubility and several camptothecin analogs and derivatives have been synthesized in an attempt to improve water solubility, bioavailability, and lactone stability. |
| Molecular Formula | C20H16N2O4 |
| References | Venditto, Vincent J. "Cancer Therapies Utilizing the Camptothecins: A Review of the in Vivo Literature." American Chemical Society (2010): 307-49. Web. |
