SKU: C145  / 
    CAS Number: 7689-03-4

    Camptothecin (Mappia foetida)

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    Camptothecin (Mappia foetida) is an alkaloid topoisomerase l (topo l) inhibitor isolated from the fungus Mappia foetida.  The compound has anti-cancer properties.
     
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    Mechanism of Action Camptothecin inhibits DNA religation in the cleavage/religation step by binding to DNA topoisomerase I (topo I) and DNA which forms a DNA topoisomerase I - camptothecin - DNA complex. This complex causes DNA damage and leads to apoptosis.
    Impurity Profile A:RRT0.90 Impurity: Not more than 0.3%
    B:RRT1.45 Impurity: Not more than 0.5%
    Total Impurities: Not more than 1.0%
    Cancer Applications Camptothecin has poor water solubility and several camptothecin analogs and derivatives have been synthesized in an attempt to improve water solubility, bioavailability, and lactone stability.
    Molecular Formula C20H16N2O4
    References Venditto, Vincent J. "Cancer Therapies Utilizing the Camptothecins: A Review of the in Vivo Literature." American Chemical Society (2010): 307-49. Web.