SKU: C079  / 
    CAS Number: 30034-03-8

    Cefamandole sodium salt

    $140.35 - $526.34

    Cefamandole sodium salt is a second generation cephalosporin antibiotic.

    TOKU-E offers two forms of cefamandole: cefamandole nafate (C078), and cefamandole sodium salt (C079). In aqueous solution, cefamandole nafate is freely soluble and sparingly soluble in methanol. Cefamandole sodium is freely soluble in an aqueous solution.

    Mechanism of ActionLike β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.
    SpectrumCefamandole is a broad spectrum cephalosporin targeting a wide variety of gram positive and gram negative bacteria.
    Microbiology ApplicationsCefamandole sodium salt is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:

    • Escherichia coli 0.08 µg/mL – 100 µg/mL
    • Klebsiella pneumoniae 0.8 µg/mL – 12.5 µg/mL
    • For a complete list of cefamandole MIC values, click here.

    Media Supplements

    Cefamandole can be used as a selective agent in several types of isolation media:

    Legionella CYE Agar - Legionella BMPA-α Selective Supplement

    Molecular FormulaC18H17N6NaO5S2
    SolubilityDMSO: Soluble
    Methanol: Soluble
    Water: Soluble
    References

    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.

    MICBacillus spp.| 0.5 - 32|| Bacteroides distasonis| >64 - >128|| Bacteroides fragilis| 8 - >128|| Bacteroides melaninogenicus| 8 - 64|| Bacteroides ovatus| 64 - >128|| Bacteroides thetaiotaomicron| 32 - >128|| Bacteroides uniformis| 64 - >128|| Bacteroides vulgatus| 32 - >128|| Bifidobacterium spp.| 1 - 64|| Brucella| 4 - >64|| Citrobacter| 0.8 - 100|| Citrobacter diversus| 0.4 - 32|| Citrobacter freundii| 0.4 - >128|| Citrobacter spp.| 0.12 - 64|| Clostridium bifermentans| 1 - 16|| Clostridium cadaveris| 1 - 16|| Clostridium difficile| 0.5 - 128|| Clostridium perfringens| 0.5 - 16|| Clostridium ramosum| 1|| Clostridium sordellii| 1 - 16|| Clostridium spp.| 0.5 - 16|| Clostridium tertium| 1 - 16|| Corynebacterium spp.| 0.5 - 32|| Diplococcus pneumoniae| 0.01 - 0.2|| Enterobacter| 1.6 - 400|| Enterobacter aerogenes| 0.8 - 128|| Enterobacter agglomerans| 0.5 - >64|| Enterobacter cloacae| 0.5 - >128|| Enterobacter gergoviae| 4 - >64|| Enterococci| >32|| Enterococcus aerogenes| 0.5 - >128|| Escherichia coli| 0.12 - 400|| Eubacterium lentum| 1 - 64|| Fusobacteria| 0.06 - 128|| Fusobacterium mortiferum| 0.5 - 128|| Fusobacterium necrophorum| 0.06 - 0.125|| Fusobacterium nucleatum| 0.125 - 1|| Fusobacterium varium| 8 - 32|| Haemophilus influenzae| 0.06 - >16|| Herellea | 6.5 - >100|| Klebsiella| 1.6 - 200|| Klebsiella oxytoca| 0.12 - 32|| Klebsiella pneumoniae| 0.012 - >128|| Klebsiella spp.| 0.25 - >128|| Lactobacillus spp.| 1 - 64|| Listeria monocytogenes| 0.5 - 32|| Micrococcus spp.| 0.5 - 32|| Morganella morganii| 0.5 - 128|| Morganella spp.| 2 - >32|| Neisseria gonorrhoeae (ESBL)| 0.002 - 4|| Neisseria meningitidis| 0.03 - 0.25|| Nocardia asteroides| 15.71|| Ochrobactrum anthropi (SLO74)| ≤128|| Peptococcus asaccharolyticus (ATCC 29743)| 1|| Peptococcus magnus | 0.12|| Peptostreptococcus anaerobius| 0.125 - 64|| Peptostreptococcus asaccharolyticus| 0.125 - 64|| Peptostreptococcus magnus| 0.125 - 64|| Peptostreptococcus tetradius| 0.125 - 64|| Porphyromonas| 0.125 - >128|| Porphyromonas asaccharolytica| 0.125 - 128|| Prevotella bivia| 2 - >128|| Prevotella buccae| 0.125 - 128|| Prevotella corporis | 0.125 - 8|| Prevotella disiens| 1 - 128|| Prevotella intermedia| 0.5 - 16|| Prevotella melaninogenica| 2 - >128|| Prevotella oralis| 0.125 - 128|| Prevotella oris| 0.125 - 128|| Propionibacterium acnes| 0.25 - 2|| Propionibacterium spp.| 0.25 - 2|| Proteus (indole-positive)| 1.6 - 400|| Proteus mirabilis| 0.2 - 30|| Proteus morganii| 0.7 - >100|| Proteus rettgeri| <0.03 - >100|| Proteus spp. (indole-positive)| 0.12 - >128|| Proteus vulgaris| 0.5 - >128|| Providencia| 0.8 - 200|| Providencia rettgeri| 32 - >64|| Providencia spp.| 0.25 - >128|| Providencia stuartii| 0.12 - >64|| Pseudomonas acidovorans| >64|| Pseudomonas aeruginosa| >64 - >128|| Pseudomonas cepacia| >64 - >100|| Pseudomonas fluorescens | >64|| Pseudomonas maltophilia| >64|| Pseudomonas putida| >64|| Pseudomonas spp.| 32 - 190.2|| Pseudomonas stutzeri| >64|| Salmonella| <0.4 - 200|| Serratia| 12.5 - 400|| Serratia marcescens| 1 - >128|| Serratia spp.| >32|| Shigella| 0.8 - 25|| Staphylococcus aureus| 0.1 - 12.5|| Staphylococcus epidermidis| 0.1 - 1.6|| Staphylococcus pyogenes| 0.03 - 0.06|| Staphylococcus saprophyticus| 2 - 5|| Streptococci (group D)| 0.12 - 64|| Streptococcus agalactiae| ≤0.12|| Streptococcus bovis| ≤0.12 - 0.5|| Streptococcus faecalis| 32|| Streptococcus faecalis| 25|| Streptococcus pneumoniae| 0.015 - 0.5|| Streptococcus pyogenes| <0.1 - 0.8|| Streptococcus viridans| ≤0.12 - 0.5||