SKU: C079  / 
    CAS Number: 30034-03-8

    Cefamandole Sodium

    R$1,048.32 - R$3,904.32
    Cefamandole Sodium

    Cefamandole sodium is a second-generation cephalosporin antibiotic. It is soluble in water, methanol, or DMSO.

    TOKU-E offers two forms of cefamandole:

    Mechanism of Action Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases.
    Spectrum Cefamandole is a broad-spectrum cephalosporin targeting a wide variety of Gram-positive and Gram-negative bacteria.
    Microbiology Applications Cefamandole sodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:
    • Escherichia coli 0.08 µg/mL – 100 µg/mL
    • Klebsiella pneumoniae 0.8 µg/mL – 12.5 µg/mL

    For a complete list of cefamandole MIC values, click here.

    Media Supplements

    Cefamandole can be used as a selective agent in several types of isolation media:

    Legionella CYE Agar - Legionella BMPA-α Selective Supplement
    Molecular Formula C18H17N6NaO5S2
    Solubility DMSO: Soluble
    Methanol: Soluble
    Water: Soluble
    References

    Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012.
    MIC Bacillus spp.| 0.5 - 32|| Bacteroides distasonis| >64 - >128|| Bacteroides fragilis| 8 - >128|| Bacteroides melaninogenicus| 8 - 64|| Bacteroides ovatus| 64 - >128|| Bacteroides thetaiotaomicron| 32 - >128|| Bacteroides uniformis| 64 － >128|| Bacteroides vulgatus| 32 － >128|| Bifidobacterium spp.| 1 － 64|| Brucella| 4 － >64|| Citrobacter| 0.8 － 100|| Citrobacter diversus| 0.4 - 32|| Citrobacter freundii| 0.4 － >128|| Citrobacter spp.| 0.12 － 64|| Clostridium bifermentans| 1 － 16|| Clostridium cadaveris| 1 － 16|| Clostridium difficile| 0.5 - 128|| Clostridium perfringens| 0.5 - 16|| Clostridium ramosum| 1|| Clostridium sordellii| 1 － 16|| Clostridium spp.| 0.5 - 16|| Clostridium tertium| 1 － 16|| Corynebacterium spp.| 0.5 - 32|| Diplococcus pneumoniae| 0.01 － 0.2|| Enterobacter| 1.6 － 400|| Enterobacter aerogenes| 0.8 - 128|| Enterobacter agglomerans| 0.5 － >64|| Enterobacter cloacae| 0.5 － >128|| Enterobacter gergoviae| 4 - >64|| Enterococci| >32|| Enterococcus aerogenes| 0.5 － >128|| Escherichia coli| 0.12 - 400|| Eubacterium lentum| 1 － 64|| Fusobacteria| 0.06 － 128|| Fusobacterium mortiferum| 0.5 － 128|| Fusobacterium necrophorum| 0.06 － 0.125|| Fusobacterium nucleatum| 0.125 － 1|| Fusobacterium varium| 8 － 32|| Haemophilus influenzae| 0.06 － >16|| Herellea | 6.5 － >100|| Klebsiella| 1.6 － 200|| Klebsiella oxytoca| 0.12 － 32|| Klebsiella pneumoniae| 0.012 - >128|| Klebsiella spp.| 0.25 － >128|| Lactobacillus spp.| 1 － 64|| Listeria monocytogenes| 0.5 - 32|| Micrococcus spp.| 0.5 - 32|| Morganella morganii| 0.5 － 128|| Morganella spp.| 2 - >32|| Neisseria gonorrhoeae (ESBL)| 0.002 - 4|| Neisseria meningitidis| 0.03 － 0.25|| Nocardia asteroides| 15.71|| Ochrobactrum anthropi (SLO74)| ≤128|| Peptococcus asaccharolyticus (ATCC 29743)| 1|| Peptococcus magnus | 0.12|| Peptostreptococcus anaerobius| 0.125 － 64|| Peptostreptococcus asaccharolyticus| 0.125 － 64|| Peptostreptococcus magnus| 0.125 － 64|| Peptostreptococcus tetradius| 0.125 － 64|| Porphyromonas| 0.125 － >128|| Porphyromonas asaccharolytica| 0.125 － 128|| Prevotella bivia| 2 － >128|| Prevotella buccae| 0.125 － 128|| Prevotella corporis | 0.125 － 8|| Prevotella disiens| 1 － 128|| Prevotella intermedia| 0.5 － 16|| Prevotella melaninogenica| 2 － >128|| Prevotella oralis| 0.125 － 128|| Prevotella oris| 0.125 － 128|| Propionibacterium acnes| 0.25 － 2|| Propionibacterium spp.| 0.25 － 2|| Proteus (indole-positive)| 1.6 － 400|| Proteus mirabilis| 0.2 - 30|| Proteus morganii| 0.7 － >100|| Proteus rettgeri| <0.03 － >100|| Proteus spp. (indole-positive)| 0.12 － >128|| Proteus vulgaris| 0.5 － >128|| Providencia| 0.8 － 200|| Providencia rettgeri| 32 - >64|| Providencia spp.| 0.25 － >128|| Providencia stuartii| 0.12 － >64|| Pseudomonas acidovorans| >64|| Pseudomonas aeruginosa| >64 - >128|| Pseudomonas cepacia| >64 - >100|| Pseudomonas fluorescens | >64|| Pseudomonas maltophilia| >64|| Pseudomonas putida| >64|| Pseudomonas spp.| 32 - 190.2|| Pseudomonas stutzeri| >64|| Salmonella| <0.4 － 200|| Serratia| 12.5 － 400|| Serratia marcescens| 1 － >128|| Serratia spp.| >32|| Shigella| 0.8 － 25|| Staphylococcus aureus| 0.1 - 12.5|| Staphylococcus epidermidis| 0.1 - 1.6|| Staphylococcus pyogenes| 0.03 － 0.06|| Staphylococcus saprophyticus| 2 - 5|| Streptococci (group D)| 0.12 － 64|| Streptococcus agalactiae| ≤0.12|| Streptococcus bovis| ≤0.12 - 0.5|| Streptococcus faecalis| 32|| Streptococcus faecalis| 25|| Streptococcus pneumoniae| 0.015 － 0.5|| Streptococcus pyogenes| <0.1 － 0.8|| Streptococcus viridans| ≤0.12 - 0.5||