Cefotetan is a cephamycin antibiotic grouped with the second-generation cephalosporins. TOKU-E offers two forms of cefotetan:
- Cefotetan (C012)
- Cefotetan Disodium (C117)
Cefotetan is sparingly soluble in water (0.51 mg/mL) and cefotetan disodium is slightly more soluble at 1 mg/mL.
| Mechanism of Action | Like β-lactams, cephamycins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactam antibiotics is commonly due to cells containing plasmid encoded β-lactamases, however, many cephamycins are unaffected by this mechanism. |
| Spectrum | Cefotetan is a broad-spectrum antibiotic targeting a wide variety of gram-positive and gram-negative bacteria. Like many cephamycins, cefotetan is very effective against anaerobic bacteria such as Bacteroides and Clostridium species. |
| Microbiology Applications | Cefotetan is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against aerobic and anaerobic gram positive and gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients. Representative MIC values include:
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| Molecular Formula | C17H17N7O8S4 |
| References | Georgopapadakou, N. H. "Mechanisms of Action of Cephalosporin 3'-quinolone Esters, Carbamates, and Tertiary Amines in Escherichia Coli." American Society for Microbiology 37.3 (1992): 559-65. Antimicrobial Agents and Chemotherapy. Web. 21 Aug. 2012. |
| MIC | Agrobacterium radiobacter| 0.25 － 8|| Alcaligenes faecalis| 0.5 － >64|| Bacteroides distasonis| ≤0.06 － 256|| Bacteroides fragilis| ≤0.06 － 512|| Bacteroides ovatus| 64 － >128|| Bacteroides thetaiotaomicron| 2 － 256|| Bacteroides uniformis| ≤0.06 － 256|| Bacteroides vulgatus| 2 － 128|| Bifidobacterium spp.| 0.5 － >128|| Bordetella bronchiseptica| 8 － >64|| Brevundimonas vesicularis| 8 － >64|| Burkholderia cepacia| 8 － >64|| Chryseobacterium indologenes| 4 － >64|| Chryseobacterium meningosepticum| ≥64|| Clostridium bifermentans| 0.25 － 4|| Clostridium cadaveris| 0.25 － 4|| Clostridium difficile| 8 － 32|| Clostridium perfringens| 1 － 4|| Clostridium sordellii| 0.25 － 4|| Clostridium spp.| 0.25 － 4|| Clostridium tertium| 0.25 － 4|| Comamonas acidovorans| 4|| Escherichia coli (NCTC 10418)| 0.06|| Eubacterium lentum| 0.5 － >128|| Finegoldia magna| 0.25 － 4|| Fusobacteria| 0.06 － 8|| Fusobacterium mortiferum| 2 － 8|| Fusobacterium necrophorum| 0.06 － 0.125|| Fusobacterium nucleatum| 0.125 － 0.5|| Fusobacterium varium| 0.5 － 4|| Lactobacillus spp.| 0.5 － >128|| Ochrobactrum anthropi| 16 － >64|| Oligella ureolytica| 0.13 － >64|| Parvimonas micra| 0.125 － 2|| Peptoniphilus gorbachii | 0.5 － 1.5|| Peptoniphilus harei | 0.38 － 8|| Peptoniphilus ivorii | 0.125 － 1|| Peptoniphilus lacrimalis | 0.016 － 0.38|| Peptoniphilus octavius | 0.5 － ?|| Peptostreptococcus anaerobius| 0.25 － 24|| Peptostreptococcus asaccharolyticus| 0.25 － 2|| Peptostreptococcus magnus| 0.25 － 2|| Peptostreptococcus tetradius| 0.25 － 2|| Porphyromonas| 0.125 － 64|| Porphyromonas asaccharolytica| 0.125 － 64|| Prevotella bivia| 2 － 16|| Prevotella buccae| 0.125 － 64|| Prevotella corporis | 0.25 － 8|| Prevotella disiens| 0.5 － 64|| Prevotella intermedia| 0.5 － 8|| Prevotella melaninogenica| 0.5 － 16|| Prevotella oralis| 0.125 － 64|| Prevotella oris| 0.125 － 64|| Propionibacterium acnes| 0.25 － 1|| Propionibacterium spp.| 0.25 － 1|| Pseudomonas aeruginosa| >64 － >128|| Pseudomonas oryzihabitans| 0.5 － >64|| Pseudomonas stutzeri| ≤0.06 － >64|| Ralstonia pickettii | 8 － >64|| Ruminococcus gnavus| 32|| Sphingomonas spp.| 64 － >64|| Staphylococcus aureus (ATCC 6571)| 4|| Stenotrophomonas maltophilia| 8 － >64|| Weeksella virosa | 0.5 － 8|| |
