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Detailed Description
CAS Number: 35607-66-0
Molecular Formula: C16H17N3O7S2
Molecular Weight: 427.46 g/mol
Mechanism of Action: Like β-lactams, cephamycins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephamycins is commonly due to cells containing plasmid encoded β-lactamases.
Storage Conditions: -20°C
Tariff Code: 2941.90.5000
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Applications
Spectrum: Cefoxitin is a broad-spectrum antibiotic effective against several Gram-positive and Gram-negative bacteria. Like many cephamycins, Cefoxitin is particularly effective against anaerobic bacteria.
Microbiology Applications: Cefoxitin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
- Bacteroides fragilis 1 µg/mL – 8 µg/mL
- Bacillus cereus 8.6 µg/mL
- For a representative list of Cefoxitin MIC values, click here.
Media Supplements
Cefoxitin can be used as a selective agent in several types of isolation media:
Clostridium difficile agar - Isolation of Clostridium difficile
Cefoxitin is a cephamycin β-lactam second-generation cephalosporin. Cefoxitin is resistant to β-lactamases. Cefoxitin is sparingly soluble in aqueous solution.
We also offer:
- Cefoxitin Sodium (C054)
CAS Number: 35607-66-0
Molecular Formula: C16H17N3O7S2
Molecular Weight: 427.46 g/mol
Mechanism of Action: Like β-lactams, cephamycins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephamycins is commonly due to cells containing plasmid encoded β-lactamases.
Storage Conditions: -20°C
Tariff Code: 2941.90.5000
Spectrum: Cefoxitin is a broad-spectrum antibiotic effective against several Gram-positive and Gram-negative bacteria. Like many cephamycins, Cefoxitin is particularly effective against anaerobic bacteria.
Microbiology Applications: Cefoxitin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options. Representative MIC values include:
- Bacteroides fragilis 1 µg/mL – 8 µg/mL
- Bacillus cereus 8.6 µg/mL
- For a representative list of Cefoxitin MIC values, click here.
Media Supplements
Cefoxitin can be used as a selective agent in several types of isolation media:
Clostridium difficile agar - Isolation of Clostridium difficile
