Cefpodoxime Sodium is a broad-spectrum, semi-synthetic, third-generation cephalosporin β-lactam and bactericidal agent that interferes with the bacterial cell wall. It is effective against a wide range of Gram-positive and Gram-negative bacteria. In vivo, it is de-esterified to the free acid and active metabolite, Cefpodoxime. Cefpodoxime, patented in 1980, is stable in the presence of β-lactamase enzymes, so many organisms resistant to penicillins and cephalosporins due to their production of β-lactamase, may be susceptible to Cefpodoxime. The compound is inactivated by certain extended-spectrum β-lactamases.
Cefpodoxime Sodium is soluble in DMSO.
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