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Detailed Description
CAS Number: 104376-79-6
Molecular Formula: C18H16N8O7S3 · 2Na · 3.5 H2O
Molecular Weight: 661.60 g/mol
Mechanism of Action: Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. Like many cephalosporins, ceftriaxone is resistant to a number of β-lactamases. Ceftriaxone can be used to study PBPs.
Storage Conditions: -20°C
Tariff Code: 2941.90.5000
Ceftriaxone Sodium, USP is the sodium salt form of Ceftriaxone, a semisynthetic, broad-spectrum, third-generation cephalosporin antibiotic that can be used in proteomics, the study of penicillin-binding proteins, and biosynthetic pathway investigation. This β-lactam is a cefotaxime derivative. The product is formulated as Ceftriaxone Sodium hemi(heptahydrate) and is freely soluble in aqueous solution.
We also offer:
- Ceftriaxone Free Acid (C074)
Ceftriaxone Sodium, USP conforms to United States Pharmacopeia specifications.
CAS Number: 104376-79-6
Molecular Formula: C18H16N8O7S3 · 2Na · 3.5 H2O
Molecular Weight: 661.60 g/mol
Mechanism of Action: Like β-lactams, cephalosporins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to cephalosporins is commonly due to cells containing plasmid encoded β-lactamases. Like many cephalosporins, ceftriaxone is resistant to a number of β-lactamases. Ceftriaxone can be used to study PBPs.
Storage Conditions: -20°C
Tariff Code: 2941.90.5000
