Monensin is a naturally occurring ionophore, commonly used in ruminant animal feed as a nonhormonal growth promoter and coccidiostat. It is a polyether antibiotic used against Gram-negative bacteria and has antiparasitic activity for dystentery prevention.
Monensin Sodium Salt is soluble in chloroform, methanol, and other organic solvents and only slightly soluble in water.
This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for questions.
|Mechanism of Action|
As an ionophore, Monensin can disrupt the natural ion gradients such as Ca2+, Mg2+, K+ and Na+, and affect transmembrane ion transport.
|Eukaryotic Cell Culture Applications||Liver microsomes were used to study the P-450 isoenzymes involved in the biotransformation of the ionophore Monensin and how it may be affected by chemotherapeutic agents. Results suggest that P-450 3A can paly an important role in the oxidative metabolism of Monensin (Nebbia et al, 1999).|
|Solubility||Soluble in chloroform, methanol, and other organic solvents and only slightly soluble in water.|
Aowicki D and Huczyński A (2013) Structure and antimicrobial properties of Monensin A and its derivatives: Summary of the achievements. Biomed Res Int. 2013:742149 PMID 23509771
Agtarap A, Chamberlin JW, Pinkerton M, Steinrauf L. (1967) The structure of monensic acid, a new biologically active compound. J Am Chem Soc. 89(22):5737-5739 PMID 5622366
Butaye, P, Devriese LA and Haesebrouck F (2003) Antimicrobial growth promoters used in animal feed: Effects of less well known antibiotics on Gram-positive bacteria. Clin. Microbiol. Rev. 16(2): 175–188
Griffiths G, Quinn P, Warren G (1983) Dissection of the Golgi complex. I. Monensin inhibits the transport of viral membrane proteins from medial to trans Golgi cisternae in baby hamster kidney cells infected with Semliki Forest virus. J Cell Biol. 1983 Mar;96(3):835-50. PMID 6682112
Lowicki, D and Huczyński A (2013). Structure and antimicrobial properties of Monensin A and its derivatives: Summary of the achievements. BioMed Res. Intl. 1–14. doi:10.1155/2013/742149