Chevalone E is a minor analogue of the meroterpenoid chevalone family, isolated from Aspergillus similanensis by researchers in Portugal. Chevalone E is closely related to the aszonapyrones and sartorypyrones. Chevalone E is synergistic when used with oxacillin against methicillin-resistant Staphylococcus aureus (MRSA) but not with ampicillin. Other members of the chevalone family show weak activity against Mycobacterium tuberculosis and tumor cell lines.
Kanokmedhakul K. et al (2011) Bioactive meroterpenoids and alkaloids from the fungus Eurotium chevalieri. Tetrahedron 67:5461
Promanya C et al (2014 New isocoumarin derivatives and meroterpenoids from the marine sponge-associated fungus Aspergillus similanensis sp. nov. KUFA 0013. Prompanya C. et al., Mar. Drugs 12:5160
Rajachan O et al (2016) Chevalone C analogues and globoscinic acid derivatives from the fungus Neosartorya spinosa KKU-1NK1. Phytochem. 132:68