Chevalone E is a minor analogue of the meroterpenoid chevalone family, isolated from Aspergillus similanensis by researchers in Portugal. Chevalone E is closely related to the aszonapyrones and sartorypyrones. Chevalone E is synergistic when used with oxacillin against methicillin-resistant Staphylococcus aureus (MRSA) but not with ampicillin. Other members of the chevalone family show weak activity against Mycobacterium tuberculosis and tumor cell lines.
| Molecular Formula | C26H38O4 |
| References | Kanokmedhakul K. et al (2011) Bioactive meroterpenoids and alkaloids from the fungus Eurotium chevalieri. Tetrahedron 67:5461 Promanya C et al (2014 New isocoumarin derivatives and meroterpenoids from the marine sponge-associated fungus Aspergillus similanensis sp. nov. KUFA 0013. Prompanya C. et al., Mar. Drugs 12:5160 Rajachan O et al (2016) Chevalone C analogues and globoscinic acid derivatives from the fungus Neosartorya spinosa KKU-1NK1. Phytochem. 132:68 |
