Co-trimoxazole ReadyMade™ Solution is provided as a sterile-filtered solution formulated in DMSO at a concentration of 100 mg/ml.
Co-trimoxazole (Syn: Trimethoprim-Sulfamethoxazole) is a combination of two anti-infectives, trimethoprim and sulfamethoxazole, in a ratio of one part trimethoprim to five parts sulfamethoxazole. A syngergistic effect has been demonstrated both in vitro and in animal studies, as they inhibit successive steps in the folate synthesis pathway. Co-trimoxazole belongs to the sulfonamide class and is bactericidal and antiparasitic in nature, useful against bacteria causing respiratory tract infections It also has immunomodulatory and anti-inflammatory properties and may be studied to ameliorate the cytokine storm syndrome associated with severe COVID-19 disease.
