Stachybotrysin B is an analogue of a complex of phenylspirodrimanes isolated from the fungus, Stachybotrys chartarum, by collaborating Chinese Key Research Institutes in 2017. Stachybotrysin B is active against HIV but is not cytotoxic.
Stachybotrysins have been shown to inhibit osteoclast differentiation in bone marrow macrophage cells via suppression of
RANKL-induced activation of p-ERK, p-JNK, p-p38, c-Fos, and NFATc1.
Zhao J et al (2017) Stachybotrysins A-G, phenylspirodrimane derivatives from the fungus Stachybotrys chartarum. J.Nat. Prod. 80:1819.