Cryptotanshinone is one of several bioactive tanshinones extracted from the Chinese medicinal herb, Salvia mitiorrhiza. It exhibits a variety of bioactivity including antibacterial, antioxidant and anti-inflammatory effects, but has more recently gained interest for its promise in the field of cancer treatment.
This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions.
This product is considered a dangerous good. Quantities above 1 g may be subject to additional shipping fees. Please contact us for specific questions.
| Mechanism of Action | Cryptotanshinone's antitumor activity comes from its ability to inhibit STAT3 phosphorylation, which downstream inhibits cell growth promoter cyclin D1, and interferes with apoptosis inhibitors survivin and Bcl-xL. |
| References | Shin, D., Kim, H., Shin, K., Yoon, Y., Kim, S., Han, D., & Kwon, B. (2008) Cryptotanshinone Inhibits Constitutive Signal Transducer and Activator of Transcription 3 Function through Blocking the Dimerization in DU145 Prostate Cancer Cells. Cancer Research, 69(1), 193-202. doi:10.1158/0008-5472.CAN-08-2575 Lee, D., Lee, S., Noh, J., & Hong, S. (1999). Antibacterial Activities of Cryptotanshinone and Dihydrotanshinone I from a Medicinal Herb, Salvia miltiorrhiza Bunge. Bioscience, Biotechnology, and Biochemistry, 63(12), 2236-2239. doi:10.1271/bbb.63.2236 |