Delta-2-Doramectin is an irreversible base degradation product of doramectin found in animals treated with doramectin and in the environment. ?2-Doramectin is formed by rearrangement of the naturally occurring ?3-group in doramectin to the 2-position. Despite the importance of doramectin as an anthelmintic in animal health, there are no published reports of the biological activity or the levels of ?2-Doramectin in animals or in the environment.
Delta-2-Doramectin is soluble in ethanol, methanol, DMF and DMSO.
Delta-2-Doramectin is soluble in ethanol, methanol, DMF and DMSO.
| References | Base-catalyzed isomerization of avermectins. Pivnichny J.V. et al. J. Agric. Food Chem. 1988, 36, 826. Direct determination of avermectins in plasma at nanogram levels by High-Performance Liquid Chromatography. Pivnichny J.V. et al. J. Pharm. Sci. 1980, 72, 1447. |
