SKU: D031  / 
    CAS Number: 127-33-3


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    Demeclocycline, a chlortetracycline analog produced by a mutagenised strain of Streptomyces aureofaciens, was first isolated in 1957. Like all tetracyclines, Demeclocycline shows broad-spectrum antibacterial and antiprotozoan activity and acts by binding to the 30S and 50S ribosomal subunits, blocking protein synthesis. Demeclocycline has been extensively cited in the literature primarily for in vivo use.

    Demeclocycline is soluble in ethanol, methanol, DMF and DMSO. 

    Molecular Formula C21H21ClN2O8
    References McCormack JRD et al (1957) A new family of antibiotics: the demethyltetracyclines. J. Am. Chem. Soc. 79: 4561

    Blackwood RK and English AR (1970)  Structure–activity relationships in the tetracycline series.  Editor(s): D. Perlman.  Adv. Appl. Microbiol. Academic Press 13:237-266