SKU: D021  / 
    CAS Number: 91296-86-5

    Difloxacin hydrochloride

    $96.38 - $397.68

    Difloxacin HCl is a fluoroquinolone antibiotic commonly used in veterinary medicine. Difloxacin HCl is freely soluble in aqueous solution (5 mg/mL).

    Mechanism of ActionFluoroquinolone antibiotics target bacterial DNA gyrase, an enzyme which reduces DNA strain during replication. Because DNA gyrase is required during DNA replication, subsequent DNA synthesis and ultimately cell division is inhibited.
    SpectrumDifloxacin is a broad spectrum antibiotic targeting a wide variety of Gram negative and Gram positive bacteria. In addition, Difloxacin is also effective against a few Mycoplasma species including Mycobacterium tuberculosis.
    Microbiology ApplicationsDifloxacin HCl is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram positive and Gram negative microbial isolates. Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients.Representative MIC values include:

    • Mycobacterium tuberculosis 0.5 µg/mL – 8 µg/mL
    • Escherichia coli 0.1875 µg/mL
    • For a complete list of difloxacin MIC values, click here.
    Molecular FormulaC21H19F2N3O3 •HCl
    References

    Wolfson, John S., and David C. Hooper. "The Fluoroquinolones: Structures, Mechanisms of Action and Resistance, and Spectra of Activity in Vitro." American Society for Microbiology 4th ser. 28 (1985): 581-86.

    MICEscherichia coli| 0.1875 - >16|| Mycobacterium tuberculosis| 0.5 - 8|| Staphylococcus aureus| 0.125||