Doxorubicin (syn: Adriamycin) is the most extensively studied of a family of highly fluorescent anthracycline antibiotics produced by several Streptomyces species, first reported in 1967 and later approved for use as an antitumor agent for a wide range of cancers. Doxorubicin also exhibits anti-HIV and antibacterial activity. The mode of action of Doxorubicin is thought to be due to intercalation of DNA and inhibition of nucleic acid synthesis.
Doxorubicin is soluble in ethanol, methanol, DMF and DMSO.
We also offer:
- Doxorubicin Hydrochloride, USP (D005)
| Mechanism of Action | Doxorubicin antimicrobial activity is thought to be due to intercalation of DNA and inhibition of nucleic acid synthesis. |
| References | Arcamone F et al (1969) Adriamycin (14-hydroxydaunomycin), a novel antitumor antibiotic. Tet. Lett. 13:1007 Fornari FL et al (1994) Interference by Doxorubicin with DNA unwinding in MCF-7 breast tumor cells. Mol. Pharmacol. 45:649 Momarier R et al (1976) Effect of Adriamycin on DNA, RNA, and protein synthesis in cell-free systems and intact cells. Cancer Res. 36:2891 |
