Emamectin B1a is a semi-synthetic 4"-epimethylamino analogue of avermectin B1a prepared by oxidation of the 4"-hydroxy moiety and reductive amination. The introduction of the methylamino group greatly enhances the insecticidal potency of the avermectin class. Emamectin B1a, as a benzoate salt, is the major component (>90%) of the commercial insecticide/acaricide, emamectin.
Emamectin B1a is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Emamectin B1a is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
| Mechanism of Action | Members of the avermectin/milbemycin class exert their insecticidal/anthelmintic effects by binding to glutamate-gated chloride channels expressed on nematode neurones and pharyngeal muscle cells. |
| References | Discovery of novel avermectins with unprecedented insecticidal activity. Mrozik H. et al. Experientia 1989, 45, 315. Synthesis of 4"-epi-amino-4"-deoxyavermectins B1. Cvetovich R.J. et al. J. Org. Chem. 1994, 59, 7704. |
