FK-506, also known as Tacrolimus, is a macrolide immunosuppressive drug commonly used post-transplant to reduce graft rejection. FK-506 is insoluble in aqueous solution.
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| Mechanism of Action | Tacrolimus forms complexes with other immune proteins which inhibit IL-2 cytokine production which ultimately suppresses T-cell proliferation and cytotoxicity. |
| Eukaryotic Cell Culture Applications | Tacrolimus can be used in mammalian cell culture to study the effects of T-cell mediated cytotoxicity. |
| References | Thomson, A. W., and C. A. Bonham. "Mode of Action of Tacrolimus (FK506): Molecular and Cellular Mechanisms." Therapeutic Drug Monitoring 17.6 (1995): 584-91.www.ncbi.gov. Pittsburgh Transplantation Institute, Dec. 1995. Web. 31 Aug. 2012. |
| MIC | Candida albicans| >10|| Cryptococcus neoformans| 12.5 － >25|| Malassezia dermatis| >32|| Malassezia furfur| 16 － ≥32|| Malassezia globosa| 16 － >32|| Malassezia japonica| ≥32|| Malassezia nana| ≥32|| Malassezia obtusa| 16 － >32|| Malassezia pachydermatis| ≥32|| Malassezia restricta| 16 - ≥32|| Malassezia slooffiae| 16 － >32|| Malassezia sympodialis| 16 － >32|| Malassezia yamatoensis| ≥32|| |