SKU: F009  / 
    CAS Number: 1847-24-1

    Flucloxacillin sodium

    $89.11 - $334.18

    Flucloxacillin sodium is a narrow spectrum β-lactam antibiotic of the penicillin class and similar in structure to cloxacillin. 

    Mechanism of Actionβ-lactams interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. PBP’s are enzymes which catalyze a pentaglycine crosslink between alanine and lysine residues providing additional strength to the cell wall. Without a pentaglycine crosslink, the integrity of the cell wall is severely compromised and ultimately leads to cell lysis and death. Resistance to β-lactams is commonly due to cells containing plasmid encoded β-lactamases. Unlike many penicillins, flucloxacillin is resistant to the degradative effects of β-lactamases.
    SpectrumFlucloxacillin targets primarily the cell wall of susceptible gram positive bacteria including Staphylococcus aureus.
    Impurity ProfileImpurity A| [3-(2-chloro-6-fluorophenyl)-5-methylisoxazol-4-yl]carbonyl]amino]methyl]-5,5-dimethylthiazolidine-4- carboxylic acid (penicilloic acids of flucloxacillin)|||| Impurity C| (2S,5R,6R)-6-Amino-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]-heptane-2-carboxylic Acid (6-Aminopenicillanic Acid)|||| Impurity D| 3-(2-Chloro-6-fluorophenyl)-5-methylisoxazole-4-carboxylic Acid||||
    Microbiology ApplicationsFlucloxacillin is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive microbial isolates.  Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients.  Representative MIC values include:

    • Staphylococcus aureus 0.1 µg/mL – 0.25 µg/mL
    • For a complete list of flucloxacillin MIC values, click here.
    Molecular FormulaC19H16ClFN3NaO5S
    References

    Guzmán, Flavio, MD. "Beta Lactams Antibiotics (penicillins and Cephalosporins) Mechanism of Action.” Medical Pharmacology. Pharmacology Corner, 29 Nov. 2008. Web. 21 Aug. 2012.

    Pitout JD, Sanders CC, Sanders WE Jr. Antimicrobial resistance with focus on beta-lactam resistance in gram-negative bacilli. Am J Med 1997; 103:51.