SKU: F005  / 
    CAS Number: 751-94-0

    Fusidic acid sodium

    $99.42 - $801.20

    Fusidic acid is a bacteriostatic steroid antibiotic which targets protein synthesis in Gram-positive bacteria. Fusidic acid sodium is highly soluble in water (50 mg/mL).

    Mechanism of ActionFusidic acid inhibits protein synthesis by preventing translocation by inhibiting ribosomal elongation factor G.
    SpectrumFusidic acid sodium targets Gram-positive bacteria namely those which cause skin infections.
    Impurity ProfileImpurity A| ent-(24SR,17Z)-16a-(acetoxy)-3b,11b,24,25-tetrahydroxy-4b,8,14-trimethyl-18-nor-5b,10a-cholest-17(20)-en-21-oic acid (24,25-dihydroxyfusidic acid)|||| Impurity C| ent-(17Z) -3b,11b-dihydroxy-17-[(6S)-6-(1-Hydroxy-1-methylethyl)-2-oxodihydro-2H-pyran-3(4H)-ylidene]-4b,8,14-trimethyl-18-nor-5b,10a-androstan-16a-yl acetate ((24R)-24,25-dihydroxyfusidic acid 21,24-lactone)|||| Impurity D| ent-(17Z) -3b,11b-dihydroxy-17-[(6R)-6-(1-hydroxy-1-methylethyl)-2-oxodihydro-2H-pyran-3(4H)-ylidene]-4b,8,14-trimethyl-18-nor-5b,10a-androstan-16a-yl acetate ((24S)-24,25-dihydroxyfusidic acid 21,24-lactone|||| Impurity E| ent-(17Z) -16a-(acetyloxy)-3b,11b,27-trihydroxy-4b,8,14-trimethyl-18-nor-5b,10a-cholesta-17(20),24-dien-21-oic acid (27-hydroxyfusidic acid)|||| Impurity F| ent-(17Z) -16a-(acetyloxy)-3b,11b,27-trihydroxy-4b,8,14-trimethyl-18-nor-5b,10a-cholesta-17(20),24-dien-21-oic acid (27-hydroxyfusidic acid)|||| Impurity K| ent-(17Z) -3b,11b,16a-trihydroxy-4b,8,14-trimethyl-18-nor-5b,10a-cholesta-17(20),24-dien-21,16-lactone(16-deacetylfusidic acid 21,16-lactone)|||| Impurity UN1| Fusidate Sodium||||
    Microbiology ApplicationsFusidic acid sodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against gram positive microbial isolates.  Medical microbiologists use AST results to recommend antibiotic treatment options for infected patients.  Representative MIC values include:

    • Methicillin resistant Staphylococcus aureus (MRSA) 0.12 µg/mL - 1.0 µg/mL
    • Streptococcus epidermidis 0.25 µg/mL
    For a complete list of fusidic acid MIC values, click here.
    ReferencesCollignon, Peter, and John Turnidge. "Fusidic Acid in Vitro Activity." International Journal of Antimicrobial Agents 12.2 (1999): 45-58. Ncbi.gov. Web. 6 Dec. 2012.
    MICBacillus subtilis| 50 - ?| 751| Borrelia burgdorferi S.L.| >4 - >4| 1129| Clostridium difficile| 0.0156 - 2| 492| Edwardsiella hoshinae| 32 - 64| 1409| Edwardsiella ictaluri| 0.13 - 64| 1409| Edwardsiella tarda| 32 - 64| 1409| Enterococcus faecalis (ATCC 29212)| 2 - ?| 401| Escherichia coli (C921-61)| 1024 - ?| 955| Escherichia coli (K-10)| >1024 - ?| 955| Escherichia coli (K-12)| 1024 - ?| 955| Escherichia coli (NCTC 10418)| >128 - ?| 401| Haemophilus influenzae| 2 - >16| 120| Moraxella catarrhalis| ≤0.03 - 0.25| 120| Salmonella typhimurium (LT2)| >1024 - ?| 955| Staphylococci| 0.03 - 128| 401| Staphylococcus aureus| 0.12 - >32| 604| Staphylococcus aureus| 0.13 - ?| 766| Staphylococcus aureus| 50 - ?| 751| Staphylococcus aureus (10389)| 0.12 - ?| 231| Staphylococcus aureus (10391)| >4 - ?| 231| Staphylococcus aureus (10397)| 0.12 - ?| 231| Staphylococcus aureus (10413)| 0.12 - ?| 231| Staphylococcus aureus (10467)| 0.12 - ?| 231| Staphylococcus aureus (10774)| 4 - ?| 231| Staphylococcus aureus (8249)| 0.06 - ?| 231| Staphylococcus aureus (8251)| 0.12 - ?| 231| Staphylococcus aureus (8258)| 0.06 - ?| 231| Staphylococcus aureus (ATCC 25923)| 0.12 - ?| 231| Staphylococcus aureus (ATCC 25923)| 0.12 - ?| 401| Staphylococcus aureus (ATCC 29213)| 0.06 - ?| 401| Staphylococcus aureus (ATCC 6571)| 0.06 - ?| 401| Staphylococcus aureus (community-acquired + methicillin-resistant)| 0.12 - 0.25| 604| Staphylococcus aureus (methicillin-resistant + mupirocin-resistant)| 0.12 - 2| 120| Staphylococcus aureus (methicillin-resistant)| 0.12 - >32| 604| Staphylococcus aureus (methicillin-resistant)| 0.12 - 2| 120| Staphylococcus aureus (methicillin-susceptible)| 0.12 - 16| 604| Staphylococcus aureus (methicillin-susceptible)| 0.12 - 1| 120| Staphylococcus aureus (vancomycin-intermediate-susceptible)| 0.062 - >64| 1060| Staphylococcus epidermidis| 0.12 - >16| 120| Staphylococcus epidermidis| 0.13 - ?| 766| Staphylococcus epidermidis (vancomycin-intermediate-susceptible)| 0.125 - 0.25| 1060| Staphylococcus haemolyticus (vancomycin-intermediate-susceptible)| 0.062 - 0.125| 1060| Staphylococcus pyogenes| 6.3 - ?| 766| Staphylococcus saprophyticus| 0.25 - 8| 120| Staphylococcus spp. (coagulase negative)| 0.06 - 32| 604| Streptococci (Viridans group)| 16 - >32| 120| Streptococcus agalactiae| 16 - 32| 120| Streptococcus pneumonia| 4 - 32| 120|