Ivermectin aglycone is a semi-synthetic produced by hydrolysing the disaccharide unit of ivermectin. Ivermectin aglycone is a potent inhibitor of nematode larval development, but is devoid of paralytic activity. The aglycone is used as a sensitive probe for the detection of some types of ivermectin resistance.
Ivermectin aglycone is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
Ivermectin aglycone is soluble in ethanol, methanol, DMF or DMSO. Poor water solubility.
| References | Ivermectin, a new broad-spectrum antiparasitic agent. Chabala J.C. et al. J. Med. Chem. 1980, 23, 1134. Detection of resistance to ivermectin in Haemonchus contortus. Gill J.G. et al. Int. J. Parasit. 1991, 21, 771. |
