Kazusamycin B is a metabolite and minor member of the Leptomycin complex isolated from some Streptomyces species. It is a hydroxylated analog of Leptomycin A, a nuclear export inhibitor. It is similar to Leptomycins A and B in physico-chemical and biological characteristics. It has anti-cancer properties. This metabolite can inhibit nuclear export and translocation of Rev, a gene product in the HIV-1 genome, at nanomolar concentrations.
Kazusamycin B is soluble in ethanol and methanol but is practically insoluble in water. It is unstable in DMSO.
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