Lefamulin Acetate is a pleuromutilin antibiotic, a group originally isolated from basidiomycetes and developed in the 1950s. Lefamulin was introduced by Nabriva Therapeutics and approved for use in US in 2019. In fact, it was the first pleuromutilin to be used for systemic treatment of bacterial infections. Chemically, it contains a tricyclic mutilin core which aids in its antimicrobial activity. Lefamulin is active against the bacteria causing CAPB (community-acquired bacterial pneumonia).
