SKU: L013  / 
    CAS Number: 75330-75-5

    Lovastatin (Mevinolin)

    $84.66 - $345.32

    Lovastatin is a statin prodrug commonly used to combat hypercholesterolemia. Lovastatin inhibits HMG-CoA reductase, a significant enzyme involved in the cholesterol synthesis pathway. Lovastatin is insoluble in aqueous solution.

    Mechanism of ActionLovastatin is an inhibitor of 3-hydroxy-3methylglutaryl-coenzyme A reductase (HMG-CoA reductase), an enzyme that catalyzes the conversion of HMG-CoA to mevalonate
    Cancer ApplicationsResearch has shown that statin drugs including lovastatin have been able to inhibit melanoma cell growth when high concentrations are used.
    References

    Eustace, A. J., and et al. "The 3-hydroxy-3-methylglutaryl-coenzyme A Reductase Inhibitors, Simvastatin, Lovastatin and Mevastatin Inhibit Proliferation and Invasion of Melanoma Cells." BMC Cancer 8.9 (2008): www.ncbi.gov. 16 Jan. 2008. Web. 31 Aug. 2012.