SKU: M075  / 
    CAS Number: 519-02-8

    Matrine

    $251.75 - $585.66
    Matrine is an alkaloid extracted from the Chinese Sophora herb plants. As a natural product it has a relatively low toxicity. Matrine has demonstrated antiviral and anti-inflammatory bioactivity. Additionally, it has been shown to induce apoptosis in many human cancer cell lines.

    TOKU-E also offers a few bioactive alkaloids similar to matrine: Oxymatrine (O031) and Oxysophocarpine (O034).

    Matrine is soluble in water, benzene, chloroform, ether, carbon disulfide.
    Mechanism of ActionKey mechanisms proposed for the antitumor effects of matrine include regulating the expression of proliferation- and apoptosis-related genes or proteins, such as eIF4E, E2F-1, Fas, FasL, Bcl-2, Bax, and caspases.
    ReferencesZhang, S., Zhang, Y., Zhuang, Y., Wang, J., Ye, J., Zhang, S., . . . Han, Y. (2012). Matrine Induces Apoptosis in Human Acute Myeloid Leukemia Cells via the Mitochondrial Pathway and Akt Inactivation. PLoS ONE, 7(10). doi:10.1371/journal.pone.0046853