Matrine is an alkaloid extracted from the Chinese herb Sophora flavescens. As a natural product, it has a relatively low toxicity. Matrine has demonstrated antiviral and anti-inflammatory bioactivity. Additionally, it has been shown to induce apoptosis in many human cancer cell lines.
Matrine is soluble in water, benzene, chloroform, ether, carbon disulfide.
We also offer:
|Mechanism of Action||Key mechanisms proposed for the antitumor effects of matrine include regulating the expression of proliferation- and apoptosis-related genes or proteins, such as eIF4E, E2F-1, Fas, FasL, Bcl-2, Bax, and caspases.|
|Cancer Research Applications||Matrine has demonstrated anti-cancer effects on various cancer cell lines. In both in vitro and in vivo studies of acute myeloid leukemia (AML) the compound inhibited cell viability and induced apoptosis in cell lines and primary AML cells in a dose and time-dependent manner (Zhang et al, 2012).|
|References||Zhang S et al (2012) Matrine induces apoptosis in human acute myeloid leukemia cells via the mitochondrial pathway and Akt inactivation. 7(10):e46853 PMID 23056487|