Mutilin is minor metabolite of the pleuromutilin family, originally isolated from Pleurotus mutilus. Mutilin is formed by hydrolysis of the hydroxyacetyl ester of pleuromutilin, and is a degradation product and in vivo metabolite of pleuromutilin. Interest in mutilin has focused on its potential as a substrate for generating unique metabolites via biosynthesis to provide a broader range of targets for semi-synthetic modification.
Mutilin is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Mutilin is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
| References | Chemical studies with pleuromutilin. Anchel M. J. Biol. Chem 1952, 199, 133. Hydroxylation of mutilin by Streptomyces griseus and Cunninghamella echinulata. Hanson R.L. et al. Org. Pro. Res. Dev. 2002, 6, 482. |
