The nanangenines are newly discovered drimane sesquiterpenoid metabolites from a hitherto undescribed Australian fungus, Aspergillus nanangensis. Nanangenine F is an acylated drimane and putative biosynthetic intermediate of the higher nanangenines. Nanangenine F is weakly active against B. subtilis (IC50 78 μg/mL) and tumor cell lines (mouse myeloma NS-1 cell, human prostate DU-145 and human breast adenocarcinoma MC-7; IC50 49 - 95 μg/mL) and neonatal foreskin cell line. The nanangenines did not exhibit Gram negative antibacterial, antifungal or herbicidal activity.
| Molecular Formula | C21H34O5 |
| References |
Lacey HJ et al (2019) Nanangenines: drimane sesquiterpenoids as the dominant metabolite cohort of a novel Australian fungus, Aspergillus nanangensis. Beilstein J Org Chem. 2019, 15, 2631. |
