Neosartoricin is a carbotricyclic metabolite produced by Aspergillus fumigatus and Neosartorya fischeri following activation of their polycyclic polyketide prenyltransferase (pcPTase)-containing silent clusters, reported by Tang and colleagues from University of California Los Angeles USA in 2013. Neosartoricin exhibits T-cell antiproliferative activity with an IC50 of 3 μM, suggesting a possible physiological role as an immunosuppressive agent.
| Molecular Formula | C26H28O9 |
| References |
Chooi Y et al (2013) Genome mining of a prenylated and immunosuppressive polyketide from pathogenic fungi. Org Lett. 15:780 Yin W et al (2013) Discovery of cryptic polyketide metabolites from dermatophytes using heterologous expression in Aspergillus nidulans. ACS Synth. Biol. 2:629 |
