Nidulin is a depsidone produced by several fungal species with potent and selective antibacterial activity.
Nidulin is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
Nidulin is soluble in ethanol, methanol, DMF or DMSO. Limited water solubility.
| Mechanism of Action | While literature relating to nidulin is limited, it is closely related to folipasatin and unguinol, both of which have been identified as inhibitors of phospholipase A2, arachidonic acid release from rat polymorphonuclear leukocytes, and nitrendipine binding to porcine heart membrane. While showing some calcium blocking attributes, these metabolites have potential as antiinflammatory agents. |
| Molecular Formula | C20H17Cl3O5 |
| References | Nidulin and ustin; two chlorine-containing metabolic products of Aspergillus nidulans. Dean F.M. et al. Nature. 1953, 172, 344. Studies on fungal products XVIII. Isolation and strucutres of a new fungal depsidone related to nidulin and a new phthalide from Emercicella unguis. Kawahara N. et al. Chem. Pharm. Bull. 1988, 36, 1970. Folipastatin, a new depsidone compound from Aspergillus unguis as an inhibitor of phospholipase A2. Hamano K. et al. J. Antibiot. 1992, 45, 1195. |
