Nigericin Sodium is an antibiotic and potassium ionophore derived from Streptomyces hygroscopicus. It exchanges potassium for hydrogen ions across biological membranes in a similar manner to Valinomycin. Nigericin Sodium also acts as an ionophore for Pb2+ with no activity with other divalent cations. Nigericin is insoluble in water but soluble in ethanol, methanol and chloroform.
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