Nigericin sodium is an antibiotic ionophore produced by Streptomyces hygroscopicus. Nigericin is insoluble in water but soluble in methanol and chloroform (10 mg/mL).
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|Mechanism of Action||Nigericin sodium acts as an antiporter of H and K ions by exchanging K for H. This ionic imbalance rapidly decreases the intracellular pH.|
|Cancer Applications||One study showed the increased intracellular acidity halted DNA synthesis in Erlich acites carcinoma lending support to use as a chemotherapeutic agent.|
|References||Margolis, Leonid B., et al. "K+/H+-antiporter Nigericin Arrests DNA Synthesis in Ehrlich Ascites Carcinoma Cells." PNAS 86 (1989): 6626-629. Pnas.org. Web. 11 Sept. 2012.|