Norstictic acid was first reported in 1934 as a metabolite produced by the lichen, Lobaria pulmonaria, along with two related
compounds. Norstictic acid has antioxidant, antimicrobial and antitumor activities. Norstictic acid treatment significantly
suppresses MDA-MB-231/GFP tumor growth of a breast cancer xenograft model in athymic nude mice.
Asahina YY and Yanagita M (1934) Lichen substances. XXXIX. A new lichen acid, norstictinic acid, and the occurrence of d-arabitol in lichens. Berichte der Deutschen Chemischen Gesellschaft [Abteilung] B: Abhandlungen 67B:799
Rankovic B. et al. (2012) Biological activities of Toninia candida and Usnea barbata together with their norstictic acid and usnic acid constituents. Int. J. Mol. Sci. 13:14797
Ebrahim HY et al.(2016) Norstictic acid inhibits breast cancer cell proliferation, migration, invasion, and in vivo invasive growth through targeting C-Met. , Phytother. Res. 30:557