Norstictic Acid was first reported in 1934 as a metabolite produced by the lichen, Lobaria pulmonaria, along with two related compounds. Norstictic acid has antioxidant, antimicrobial and antitumor activities. Norstictic Acid significantly suppresses MDA-MB-231/GFP tumor growth in a breast cancer xenograft model in athymic nude mice.
Norstictic Acid is soluble in ethanol, methanol, DMF or DMSO.
| Molecular Formula | C18H12O9 |
| Eukaryotic Cell Culture Applications | A natural product, Norstictic Acid functions through an alternative binding site to block Med25–transcriptional activator PPIs in vitro and in cell culture. |
| Cancer Applications |
Research has indicated that dysregulation of transcriptional protein-protein interactions (PPIs) network of Med25 and the ETV/PEA3 transcriptional activators contribute to oncogenesis as well as metastatic phenotypes in certain breast and prostate cancers, emphasizing a need for Med25-selective inhibitors. Authors report the discovery of the natural product Norstictic Acid as the first type of inhibitor that functions this way. Norstictic Acids alters Med25-driven transcription in a model of triple-negative breast cancer (Garlick et al, 2021). |
| References |
Asahina YY and Yanagita M (1934) Lichen substances. XXXIX. A new lichen acid, Norstictinic Acid, and the occurrence of d-arabitol in lichens. Berichte der Deutschen Chemischen Gesellschaft [Abteilung] B: Abhandlungen 67B:799 Ebrahim HY et al.(2016) Norstictic Acid inhibits breast cancer cell proliferation, migration, invasion, and in vivo invasive growth through targeting C-Met. , Phytother. Res. 30:557 Garlick JM et al (2021) Norstictic Acid is a selective allosteric transcriptional regulator. J. Am. Chem. Soc. 2021 143(25):9297-9302 PMID 34137598 Rankovic B. et al. (2012) Biological activities of Toninia candida and Usnea barbata together with their Norstictic Acid and usnic acid constituents. Int. J. Mol. Sci. 13:14797 |
